The Importance and Control of the Nucleation Process for the Crystallization of Pharmaceutical Substances
DOI:
https://doi.org/10.54779/chl20220737Keywords:
crystallization of pharmaceutical substances, nucleation and crystallization process control, seeded crystallization, sonocrystallization, FBRM technique, Blaze systemAbstract
The text is a contemporary continuation of an earlier publication, Kratochvíl B.: Chem. Listy 101, 3 (2007). It describes mainly the nucleation process (two-step nucleation of active substances in pharmacy) and crystallization control processes (seeded crystallization and sonocrystallization). The focus of the work is the description of the nucleation process monitoring by modern analytical technologies, i.e., Focused Beam Reflectance Measurement (FBRM) and the BlazeMetrics system. Both methods presently provide the best available information for a deeper understanding of the nucleation process mechanism in crystallizing active substances. The work is documented by high quality and original photographic attachments of the crystallizing material.
Full text English translation is available in the on-line version.
